Storage:
active substance: tetryzoline;
1 ml of the drug contains tetrahydrozoline hydrochloride in 100% dry substance 0.5 mg;
excipients: benzalkonium chloride; sodium dihydrogen phosphate, dihydrate; sodium hydrogen phosphate, dodecahydrate; sodium chloride; disodium edetate; water for injections.
Medicinal form. Eye drops.
Main physico-chemical properties: transparent, colorless, odorless liquid.
Pharmacotherapeutic group. Means used in ophthalmology. Anti-edematous and anti-allergic agents. Sympathomimetics used as anti-edema agents. Tetrizoline. ATX code S01G A02.
Pharmacological properties.
Pharmacodynamics.
Tetrizoline is a sympathomimetic agent that belongs to the group of imidazoline decongestants. It directly stimulates alpha-adrenergic receptors of the sympathetic nervous system with little or no effect on beta-adrenergic receptors. When applied locally to the mucous membrane of the conjunctiva, the drug exerts a temporary vasoconstrictive effect on small blood vessels, thereby reducing vasodilation and swelling of the conjunctiva.
Pharmacokinetics.
After therapeutic ocular administration, tetrizoline was detected in blood serum and urine. The average half-life of tetrizoline from blood serum was approximately 6 hours. Systemic absorption in patients varied, the maximum concentration in blood serum was in the range of 0.068 to 0.380 ng/ml. After 24 hours, tetrizoline was detected in urine in all patients.
Clinical characteristics.
Indication.
Symptomatic temporary relief of secondary eye hyperemia due to moderate irritant effect.
Contraindication.
Hypersensitivity to the components of the drug, angle-closure glaucoma.
Interaction with other medicinal products and other types of interactions.
There are no known significant interactions with other medicinal products. Consult a doctor before using with other ophthalmic drugs.
Overdose.
When using the drug according to the recommendations, an overdose is unlikely.
With an overdose of the drug, an increase in hyperemia or reactive hyperemia may be observed.
Symptoms that can be observed after ingestion or excessive use of the drug: bradycardia, drowsiness, lowering of blood pressure, apathy and lowering of body temperature. Additional symptoms that can be observed only after swallowing the drug can be apnea, depression of the central nervous system and coma, respiratory depression, possible development of reactions from the cardiovascular system.
Treatment. When the drug is swallowed, the treatment consists in taking activated charcoal and emptying the stomach. Further treatment should be symptomatic and supportive.
Adverse reactions.
Very rarely (<0.01%), adverse reactions associated with the use of tetrahydrozoline hydrochloride have been observed in the post-registration period. Reactions at the site of application (including burning sensation in the eyes and periocular area, irritation of the mucous membrane of the eyes, pain in the eyes, itching, erythema, tearing in the eyes, dilation of the pupils (mydriasis), reactive hyperemia of the eye ("ricochet" hyperemia of the eye)). Systemic sympathomimetic effects can sometimes occur. Hypersensitivity reactions may occur in patients with increased sensitivity to the components of the medicinal product. Expiry date. 3 years. The shelf life of the drug after opening the bottle is 28 days. Do not use the drug after the expiration date indicated on the package. Storage conditions. Store in the original packaging at a temperature not higher than 25 ºС. Keep out of the reach of children. Packaging. 10 ml bottle. 1 bottle in a pack. Release category. Without a prescription. Producer. "Farmak" JSC. Buy [product_title] Price of [product_title] Order online [product_title] Where to buy [product_title] Cost of [product_title] Cheapest price for [product_title] Find in pharmacy [product_title] Buy online [product_title] Discount on [product_title] Online store for [product_title] Купить [product_title] Цена [product_title] Заказать [product_title] Где купить [product_title] [product_title] в аптеке Стоимость [product_title] [product_title] недорого Онлайн покупка [product_title] [product_title] в интернет-аптеке [product_title] с доставкой Acheter [product_title] Prix de [product_title] Commander en ligne [product_title] Où acheter [product_title] [product_title] en pharmacie Coût de [product_title] Prix bas pour [product_title] Acheter en pharmacie [product_title] Livraison de [product_title] [product_title] en promotion Comprar [product_title] Precio de [product_title] Ordenar en línea [product_title] Dónde comprar [product_title] [product_title] en farmacia Costo de [product_title] [product_title] barato Compra en línea [product_title] [product_title] en oferta [product_title] con envío
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